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Appl Environ Microbiol. 2005 Jan;71(1):562-5.

Maturation by LctT is required for biosynthesis of full-length lantibiotic lacticin 481.

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  • 1Laboratoire de Biotechnologie et Chimie Marines, EA 3884, Université de Bretagne Sud, BP 92116, 56321 Lorient Cedex, France.

Abstract

In lantibiotic lacticin 481 biosynthesis, LctT cleaves the precursor peptide and exports mature lantibiotic. Matrix-assisted laser desorption ionization-time of flight mass spectrometry revealed that a truncated form of lacticin 481 is produced in the absence of LctT or after cleavage site inactivation. Production of truncated lacticin 481 is 4-fold less efficient, and its specific activity is about 10-fold lower.

PMID:
15640237
PMCID:
PMC544215
DOI:
10.1128/AEM.71.1.562-565.2005
[PubMed - indexed for MEDLINE]
Free PMC Article
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