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Exp Parasitol. 2005 Jan;109(1):33-7. Epub 2004 Dec 15.

Leishmania major: clathrin and adaptin complexes of an intra-cellular parasite.

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Department of Biological Sciences, Centre for Molecular Microbiology and Infection, Imperial College, London SW7 2AY, UK.


To investigate the role of clathrin-mediated trafficking during the Leishmania lifecycle, open reading frames encoding clathrin heavy chain and the beta-adaptins, major components of the adaptor complexes, have been analysed both in silico and experimentally. The Leishmania genome encodes three beta-adaptins, which arose at a time predating speciation of these divergent trypanosomatids. Unlike Trypanosoma brucei, both clathrin heavy chain and beta-adaptin1 are constitutively expressed throughout the Leishmania life cycle. Clathrin relocalises in amastigotes relative to promastigotes, consistent with developmental alterations to the morphology of the endo-membrane system.

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