Format

Send to

Choose Destination
Exp Parasitol. 2005 Jan;109(1):33-7. Epub 2004 Dec 15.

Leishmania major: clathrin and adaptin complexes of an intra-cellular parasite.

Author information

1
Department of Biological Sciences, Centre for Molecular Microbiology and Infection, Imperial College, London SW7 2AY, UK. p.w.denny@durham.ac.uk

Abstract

To investigate the role of clathrin-mediated trafficking during the Leishmania lifecycle, open reading frames encoding clathrin heavy chain and the beta-adaptins, major components of the adaptor complexes, have been analysed both in silico and experimentally. The Leishmania genome encodes three beta-adaptins, which arose at a time predating speciation of these divergent trypanosomatids. Unlike Trypanosoma brucei, both clathrin heavy chain and beta-adaptin1 are constitutively expressed throughout the Leishmania life cycle. Clathrin relocalises in amastigotes relative to promastigotes, consistent with developmental alterations to the morphology of the endo-membrane system.

PMID:
15639137
DOI:
10.1016/j.exppara.2004.10.007
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center