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Protein Pept Lett. 2005 Jan;12(1):31-9.

Amphiphilic alpha-helical antimicrobial peptides and their structure/function relationships.

Author information

1
Department of Forensic and Investigative Science, University of Central Lancashire, Preston, UK.

Abstract

To facilitate microbial membrane invasion, amphiphilic alpha-helical antimicrobial peptides (alpha-AMPs) show a spatial segregation of hydrophobic and hydrophilic residues about the alpha-helical long axis. Here we discuss potential mechanisms by which these peptides are able to disrupt membrane structure and the structural characteristics, which are required for function.

PMID:
15638801
[Indexed for MEDLINE]

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