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Lipids Health Dis. 2005 Jan 6;4:1.

Association of SNP3 polymorphism in the apolipoprotein A-V gene with plasma triglyceride level in Tunisian type 2 diabetes.

Author information

1
Biochemistry laboratory, UR 08-39, Faculty of Medicine MONASTIR, Tunisia. rchaaba@yahoo.fr

Abstract

BACKGROUND:

Apolipoprotein A-V (Apo A-V) gene has recently been identified as a new apolipoprotein involved in triglyceride metabolism. A single nucleotide polymorphism (SNP3) located in the gene promoter (-1131) was associated with triglyceride variation in healthy subjects. In type 2 diabetes the triglyceride level increased compared to healthy subjects. Hypertriglyceridemia is a risk factor for coronary artery disease. We aimed to examine the interaction between SNP3 and lipid profile and coronary artery disease (CAD) in Tunisian type 2 diabetic patients.

RESULTS:

The genotype frequencies of T/T, T/C and C/C were 0.74, 0.23 and 0.03 respectively in non diabetic subjects, 0.71, 0.25 and 0.04 respectively in type 2 diabetic patients. Triglyceride level was higher in heterozygous genotype (-1131 T/C) of apo A-V (p = 0.024). Heterozygous genotype is more frequent in high triglyceride group (40.9%) than in low triglyceride group (18.8%); p = 0.011. Despite the relation between CAD and hypertriglyceridemia the SNP 3 was not associated with CAD.

CONCLUSION:

In type 2 diabetic patients SNP3 is associated with triglyceride level, however there was no association between SNP3 and coronary artery disease.

PMID:
15636639
PMCID:
PMC545942
DOI:
10.1186/1476-511X-4-1
[Indexed for MEDLINE]
Free PMC Article

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