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Zhonghua Zhong Liu Za Zhi. 2004 Oct;26(10):598-600.

[Frequent genetic deletion of detoxifying enzyme GSTM1 and GSTT1 genes in nasopharyngeal carcinoma patients in Guangxi Province, China].

[Article in Chinese]

Author information

1
Department of Pathology, Guangxi Medical University, Nanning 530021, China. zhuolindeng@hotmail.com

Abstract

OBJECTIVE:

To study the genetic susceptibility to chemical carcinogens of nasopharyngeal carcinoma (NPC) patients in a high-risk area in Guangxi.

METHODS:

PCR technique was used to examine the frequency of glutathione S-transferase M1 and T1 gene deletion in a matched case-control study of 91 patients with NPC and 135 control subjects.

RESULTS:

The deletion frequency of control subjects was 47.4% (65/135) for GSTM1 and 40.7% (55/135) for GSTT1, whereas that of NPC patients was 61.5% (56/91) for GSTM1 and 59.3% (54/91) for GSTT1 with statistically significant difference between the patients and the controls (P < 0.05 and P < 0.01). Furthermore, the frequency of codeletion of both genes was also higher in NPC patients than the control with statistically significant difference (chi2 = 12.533, P = 0.002).

CONCLUSION:

In high-risk area, nasopharyngeal carcinoma patients and local residents have high frequency of GSTM1 and/or GSTT1 gene deletion. It suggests that a genetic susceptibility to putative chemical carcinogens may be responsible for NPC clustering in the high-risk area studied.

PMID:
15634519
[Indexed for MEDLINE]

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