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Steroids. 2005 Feb;70(2):103-10. Epub 2004 Dec 15.

First synthesis of a pentadeuterated 3'-hydroxystanozolol--an internal standard in doping analysis.

Author information

1
Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9, A-1060 Vienna, Austria.

Abstract

The first synthesis of 16,16,20,20,20-pentadeuterio-3'-hydroxystanozolol (8) in 26% yield over nine steps is described using moderately priced starting materials and economic amounts of reagents. Compound 8 can be used as an internal standard in screening procedures for anabolic steroids as well as for the quantification of stanozolol metabolites via mass spectrometric techniques, such as LC-MS or gas chromatography-mass spectrometry (GC-MS).

PMID:
15631866
DOI:
10.1016/j.steroids.2004.10.002
[Indexed for MEDLINE]

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