Format

Send to

Choose Destination
See comment in PubMed Commons below
J Clin Invest. 2005 Jan;115(1):29-32.

Mac the knife? Macrophages- the double-edged sword of hepatic fibrosis.

Author information

1
Division of Liver Diseases, Mount Sinai School of Medicine, New York, New York 10029, USA. Scott.Friedman@mssm.edu

Abstract

Progression of hepatic fibrosis requires sustained inflammation leading to activation of stellate cells into a fibrogenic and proliferative cell type, whereas regression is associated with stellate cell apoptosis. The contribution of hepatic macrophages to these events has been largely overlooked. However, a study in this issue of the JCI demonstrates that macrophages play pivotal but divergent roles, favoring ECM accumulation during ongoing injury but enhancing matrix degradation during recovery. These findings underscore the potential importance of hepatic macrophages in regulating both stellate cell biology and ECM degradation during regression of hepatic fibrosis.

PMID:
15630440
PMCID:
PMC539205
DOI:
10.1172/JCI23928
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Journal of Clinical Investigation Icon for PubMed Central
    Loading ...
    Support Center