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Nat Rev Immunol. 2005 Jan;5(1):21-30.

WNT signalling and haematopoiesis: a WNT-WNT situation.

Author information

1
Department of Immunology, Room Ee 838, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands. f.staal@erasmusmc.nl

Abstract

The evolutionarily conserved WNT-signalling pathway has pivotal roles during the development of many organ systems, and dysregulated WNT signalling is a key factor in the initiation of various tumours. Recent studies have implicated a role for WNT signal transduction at several stages of lymphocyte development and in the self-renewal of haematopoietic stem cells. Here, we outline new insights into the WNT-signalling pathway, review its role in the self-renewal of haematopoietic stem cells and in the development of T and B cells, and discuss controversies and future developments with regard to WNT signalling in the thymus.

PMID:
15630426
DOI:
10.1038/nri1529
[Indexed for MEDLINE]

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