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Biochem Biophys Res Commun. 2005 Feb 4;327(1):208-11.

Ritonavir does not inhibit calpain in vitro.

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  • 1Department of Biochemistry, Queen's University, Kingston, Ont., Canada K7L 3N6.

Abstract

Ritonavir, an inhibitor of HIV-1 protease, has been reported to also inhibit the Ca2+-dependent cysteine protease, calpain. We have investigated these claims with an in vitro study of the effect of ritonavir on the m-calpain and mu-calpain isoforms. Ritonavir failed to block either autolytic or hydrolytic calpain activity, but remained fully capable of inhibiting the HIV-1 protease. Any calpain-related effects of ritonavir in cells must, therefore, arise by a mechanism other than direct inhibition of calpains.

PMID:
15629450
DOI:
10.1016/j.bbrc.2004.11.161
[PubMed - indexed for MEDLINE]
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