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Trends Immunol. 2005 Jan;26(1):9-12.

A new twist to the leukocyte adhesion cascade: intimate cooperation is key.

Author information

1
Department of Biological Sciences, Box 413, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA. steeber@uwm.edu

Abstract

Leukocyte migration from blood into lymphoid and non-lymphoid tissues requires a highly orchestrated series of adhesive and signaling events. A network of adhesion molecules with overlapping functions mediate the capture, rolling and firm adhesion of leukocytes to the vascular endothelium. A new study adds a novel twist to this paradigm by demonstrating that two adhesion molecules, CD44 and VLA-4, must be physically associated with each other on activated T cells to mediate efficient rolling and firm adhesion.

PMID:
15629403
DOI:
10.1016/j.it.2004.11.012
[Indexed for MEDLINE]

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