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Construction of a non-redundant human SH2 domain database.

Author information

1
Department of Pathophysiology/National Key Laboratory of Medical Molecular Biology/Proteomics Research Center, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing 100005, China.

Abstract

Domain database is essential for domain property research. Eliminating redundant information in database query is very important for database quality. Here we report the manual construction of a non-redundant human SH2 domain database. There are 119 human SH2 domains in 110 SH2-containing proteins. Human SH2s were aligned with ClustalX, and a homologous tree was generated. In this tree, proteins with similar known function were classified into the same group. Some proteins in the same group have been reported to have similar binding motifs experimentally. The tree might provide clues about possible functions of hypothetical proteins for further experimental verification.

PMID:
15629051
PMCID:
PMC5172440
DOI:
10.1016/s1672-0229(04)02017-0
[Indexed for MEDLINE]
Free PMC Article

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