[Modification of antitumor effect of vincristine by natural avermectins]

V A Driniaev; V A Mosin; E B Krugliak; T C Sterlina; T C Novik; N V Ermakova; L N Kublik; M Kh Levitman; V V Shaposhnikova; Iu N Korystov

[Modification of antitumor effect of vincristine by natural avermectins]

Antibiot Khimioter. 2004;49(6):3-5.

[Article in Russian]

Authors

V A Driniaev, V A Mosin, E B Krugliak, T C Sterlina, T C Novik, N V Ermakova, L N Kublik, M Kh Levitman, V V Shaposhnikova, Iu N Korystov

PMID: 15628794

Abstract

The effect of avermectins (aversectin C, aversectin C1 and avermectin B1) on the vincristine antitumor action with respect to murine transplantable tumors was studied. It was shown that both the natural avermectins mixtures and the individual avermectin B1 potentiated the antitumor action of vincristine on Ehrlich carcinoma, melanoma B16 and P388 lymphoid leukemia, including the vincristine resistant strain P388. Such an effect of the avermectins was observed only when they were administered after vincristine.

Publication types

English Abstract

MeSH terms

Animals
Antineoplastic Agents, Phytogenic / administration & dosage
Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
Antiparasitic Agents / administration & dosage
Dose-Response Relationship, Drug
Ivermectin / administration & dosage
Ivermectin / analogs & derivatives
Mice
Mice, Inbred DBA
Neoplasm Transplantation
Neoplasms, Experimental / drug therapy*
Vincristine / administration & dosage

Substances

Antineoplastic Agents, Phytogenic
Antiparasitic Agents
Vincristine
Ivermectin
avermectin