Send to

Choose Destination
Cancer Causes Control. 1992 Mar;3(2):145-51.

Prospective study of the association of alcohol with cancer of the upper aerodigestive tract and other sites.

Author information

Division of Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan.


The association of alcohol consumption with cancers of the upper aerodigestive tract, hepato-biliary-pancreatic system, urogenital organs (except for prostate), and lymphohematopoietic tissue was evaluated in a prospective study of 6,701 American men of Japanese ancestry living in Hawaii. Compared with cancer-free subjects, subjects who subsequently developed cancers of the upper aerodigestive tract (oral-pharynx, esophagus, and larynx), liver, biliary tract, and lymphohematopoietic tissue consumed significantly larger amounts of total alcohol--mainly in the form of beer. Subjects who developed oral-pharyngeal and esophageal cancer also consumed larger amounts of wine and spirits. Because the upper aerodigestive tract cancers were associated positively with cigarette smoking, age-adjusted relative risks (RR) were calculated, based on joint exposure to cigarette smoking and heavy alcohol intake (greater than or equal to 30 ml/day) in this population. A markedly increased risk was observed among subjects who were both heavy alcohol drinkers and smokers (RR = 17.3, 95 percent confidence interval [CI] = 6.7-44.2), compared with subjects who who did not smoke and did not drink heavily. The risk for these cancers also was increased among heavy alcohol drinkers who were nonsmokers (RR = 8.6, CI = 2.1-36.0).

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center