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Neurology. 2004 Dec 28;63(12):2399-401.

Neurofibrillary tangles in ALS and Parkinsonism-dementia complex focus in Kii, Japan.

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1
Department of Neurology, Mie University School of Medicine, Tsu, Mie-ken, Japan.

Abstract

Brains of 41 residents without neurodegenerative diseases in the high-incidence area of ALS/parkinsonism-dementia complex (ALS/PDC) of the Kii Peninsula of Japan were neuropathologically examined. Neurofibrillary tangles (NFTs) in the hippocampal area were present in 11 of the 41 cases, but the frequency of NFT-positive cases in each age group was similar to that of the normal Japanese population and far less than that of Guamanians without ALS/PDC.

PMID:
15623711
[Indexed for MEDLINE]
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