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FEMS Microbiol Lett. 2005 Jan 15;242(2):287-95.

GeneChip expression analysis of the VqsR regulon of Pseudomonas aeruginosa TB.

Author information

1
Clinical Research Group OE 6711, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany. juhas.mario@mh-hannover.de

Abstract

Two interlinked quorum sensing circuits, las and rhl, which control pathogenesis of Pseudomonas aeruginosa are further modulated by numerous regulators, including VqsR (virulence and quorum sensing regulator). High-density oligonucleotide microarrays were used to compare the global expression profile of a wild-type and VqsR mutant in ABC minimal medium. The expression of a large group of metabolic genes, ECF sigma factors as well as of many quorum-sensing genes previously not assigned to VqsR-regulon was found to be affected by the disruption of vqsR.

PMID:
15621450
DOI:
10.1016/j.femsle.2004.11.020
[Indexed for MEDLINE]
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