Format

Send to

Choose Destination
Trends Endocrinol Metab. 2005 Jan-Feb;16(1):26-33.

"Ins and outs" of seven-transmembrane receptor signalling to ERK.

Author information

1
Department of Pharmacology, University of Melbourne, Parkville, Victoria 3010, Australia.

Abstract

Extracellular-signal-regulated kinases 1 and 2 (ERK1/2) are important members of the mitogen-activated protein kinase (MAPK) family and have emerged as key effector targets of activation by seven-transmembrane-spanning (G-protein-coupled) receptors (7TMRs). Regulation of ERK by 7TMRs is highly complex and dependent on cell type. Numerous studies have linked specific G protein pathways to ERK activation, but recent evidence suggests that some 7TMR-linked ERK signalling pathways might not be exclusively mediated by G proteins. In addition, the emergence of an "inside-out" model for receptor tyrosine kinase (RTK) "transactivation" by 7TMRs has enhanced our understanding of the ERK signalling system and further underscores the complexity of mitogenic regulation by 7TMRs.

PMID:
15620546
DOI:
10.1016/j.tem.2004.11.008
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center