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Cell. 2004 Dec 29;119(7):903-6.

A crack in histone lysine methylation.

Author information

1
Research Institute of Molecular Pathology, The Vienna Biocenter, Dr. Bohrgasse 7, A-1030 Vienna, Austria.

Abstract

Histone lysine methylation is regarded as a very stable modification with important functions in epigenetic gene control and for organizing chromatin domains. While more robust modifications of the chromatin template are essential to stabilize epigenetic information, there is now the first evidence for a histone lysine demethylase that reverts an activating methyl mark to the unmodified state (Shi et al., 2004 [this issue of Cell]).

PMID:
15620348
DOI:
10.1016/j.cell.2004.12.006
[Indexed for MEDLINE]
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