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Nat Med. 2005 Jan;11(1):32-4. Epub 2004 Dec 26.

Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue.

Author information

1
Transplantation Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts 02129, USA.

Abstract

The use of animal organs could potentially alleviate the critical worldwide shortage of donor organs for clinical transplantation. Because of the strong immune response to xenografts, success will probably depend upon new strategies of immune suppression and induction of tolerance. Here we report our initial results using alpha-1,3-galactosyltransferase knockout (GalT-KO) donors and a tolerance induction approach. We have achieved life-supporting pig-to-baboon renal xenograft survivals of up to 83 d with normal creatinine levels.

PMID:
15619627
DOI:
10.1038/nm1172
[Indexed for MEDLINE]

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