Polymorphism of MDR1 gene in healthy japanese subjects: a novel SNP with an amino acid substitution (Glu108Lys)

Tomohiro Honda; Yukihiko Dan; Noriko Koyabu; Ichiro Ieiri; Kenji Otsubo; Shun Higuchi; Hisakazu Ohtani; Yasufumi Sawada

doi:10.2133/dmpk.17.479

Polymorphism of MDR1 gene in healthy japanese subjects: a novel SNP with an amino acid substitution (Glu108Lys)

Drug Metab Pharmacokinet. 2002;17(5):479-81. doi: 10.2133/dmpk.17.479.

Authors

Tomohiro Honda¹, Yukihiko Dan, Noriko Koyabu, Ichiro Ieiri, Kenji Otsubo, Shun Higuchi, Hisakazu Ohtani, Yasufumi Sawada

Affiliation

¹ Division of Biopharmaceutics, Department of Medico-Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.

PMID: 15618700
DOI: 10.2133/dmpk.17.479

Abstract

We discovered a novel single nucleotide polymorphism (SNP) at position 325 (G325A) in exon 5 of the multidrug-resistance 1 (MDR1) gene in a study of 37 healthy Japanese subjects. Details are as follows. SNP, 020614Honda001; GENE NAME, human P-glycoprotein (MDR1); ACCESSION NUMBER, M29427; LENGTH, 25 bases; 5'-ATGAATCTGGAGG/AAAGACATGACCA-3'. This SNP is expected to cause an amino acid substitution (Glu108Lys). In this study, one homozygote and one heterozygote for G325A were identified.