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J Fluoresc. 2004 Jul;14(4):369-75.

Microstructured arrays with pre-synthesized capture probes for DNA detection based on metal nanoparticles and silver enhancement.

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1
Institute for Physical High Technology, PO Box 100239, 07702 Jena, Germany.

Abstract

DNA microarrays exhibiting highly defined squared spot geometry and increased homogeneity in capture DNA distribution were prepared by a combination of microfabrication and DNA spotting. The microfabricated substrates were tested using metal nanoparticles as markers. The optical absorption signal is improved by a silver enhancement step. Experiments demonstrated the specificity and the concentration-dependency of the signal.

PMID:
15617379
[Indexed for MEDLINE]
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