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Antimicrob Agents Chemother. 2005 Jan;49(1):444-6.

Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis in Brazil.

Author information

1
Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Rua Bento Gonçalves 9500, Prédio 43421, CEP 91501-970 Porto Alegre, RS, Brazil.

Erratum in

  • Antimicrob Agents Chemother. 2006 Nov;50(11):3970.

Abstract

In this study the nucleotide sequence of the pncA gene from 59 Mycobacterium tuberculosis clinical isolates was analyzed. Mutations in the pncA gene were identified in 29 of 40 pyrazinamide-resistant isolates, and no pyrazinamidase activity was detected in 39 of them. Twelve mutations found in this work have not been described previously.

PMID:
15616332
PMCID:
PMC538919
DOI:
10.1128/AAC.49.1.444-446.2005
[Indexed for MEDLINE]
Free PMC Article

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