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Transplantation. 2004 Dec 27;78(12):1774-9.

Control of organ transplant-associated graft-versus-host disease by activated host lymphocyte infusions.

Author information

1
Department of Hematology, Johannes Gutenberg-University, Mainz, Germany. J.Kuball@gmx.de

Abstract

BACKGROUND:

Prolonged persistence of donor-derived T cells after organ transplantation has been proposed to improve long-term allograft survival. However, surviving transplant-derived T cells are also able to mediate devastating graft-versus-host disease (GvHD). Currently, GvHD after organ transplantation is usually refractory to conventional therapy and the disease outcome fatal.

METHODS:

Graft-reactive host T cells were generated ex vivo from a patient suffering from a severe and refractory liver-transplant-associated GvHD. To control GvHD, activated alloreactive host T cells were repetitively retransferred into the patient (activated host lymphocyte infusion [aHLI]).

RESULTS:

Adoptive transfer of ex vivo activated alloreactive host T cells (aHLI) led to the control and complete resolution of severe GvHD without inducing allograft rejection.

CONCLUSIONS:

aHLI opens a novel therapeutic window to control solid-organ transplant-associated GvHD while preserving allograft integrity.

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PMID:
15614150
[Indexed for MEDLINE]

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