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J Am Chem Soc. 2004 Dec 29;126(51):16742-3.

Formation of the aureothin tetrahydrofuran ring by a bifunctional cytochrome p450 monooxygenase.

Author information

1
Hans-Knöll-Institute for Natural Products Research, Beutenbergstrasse 11a, 07745 Jena, Germany.

Abstract

The polyketide antibiotic aureothin, produced by Streptomyces thioluteus, is equipped with a rare exomethylene-tetrahydrofuran moiety. Cloning, heterologous expression, and inactivation experiments reveal that AurH, a bifunctional cytochrome P450 monooxygenase, is required and sufficient for the stereoselective synthesis of the furan ring, involving the subsequent formation of two new C-O bonds.

PMID:
15612710
DOI:
10.1021/ja046104h
[Indexed for MEDLINE]

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