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Genetics. 2004 Dec;168(4):1817-25.

Spontaneous mutations in diploid Saccharomyces cerevisiae: more beneficial than expected.

Author information

1
Section of Integrative Biology, University of Texas, Austin, Texas 78712, USA.

Abstract

We performed a 1012-generation mutation-accumulation (MA) experiment in the yeast, Saccharomyces cerevisiae. The MA lines exhibited a significant reduction in mean fitness and a significant increase in variance in fitness. We found that 5.75% of the fitness-altering mutations accumulated were beneficial. This finding contradicts the widely held belief that nearly all fitness-altering mutations are deleterious. The mutation rate was estimated as 6.3 x 10(-5) mutations per haploid genome per generation and the average heterozygous fitness effect of a mutation as 0.061. These estimates are compatible with previous estimates in yeast.

PMID:
15611159
PMCID:
PMC1448740
DOI:
10.1534/genetics.104.033761
[Indexed for MEDLINE]
Free PMC Article

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