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Mol Cell. 2004 Dec 22;16(6):861-5.

Transcription and processing of human microRNA precursors.

Author information

1
Howard Hughes Medical Institute and Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA. culle002@mc.duke.edu

Abstract

MicroRNAs have recently emerged as key posttranscriptional regulators of eukaryotic gene expression, yet our understanding of how microRNA expression is itself controlled has remained rudimentary. This review describes recent insights into the mechanisms governing microRNA transcription and processing in vertebrates and their implications for understanding the regulation of microRNA biogenesis.

PMID:
15610730
DOI:
10.1016/j.molcel.2004.12.002
[Indexed for MEDLINE]
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