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Springer Semin Immunopathol. 2005 Jan;26(3):247-55. Epub 2004 Oct 14.

Induction of antigen cross-presentation by Toll-like receptors.

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University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0663, USA.


Cross-presentation is the pathway by which exogenous antigens are routed for presentation on MHC class I for activation of CD8(+) T cells. This pathway is important for the development of CD8(+) cytotoxic T lymphocyte responses against tumors and infectious pathogens that do not directly infect APC. We review studies showing that certain Toll-like receptors mediate cross-presentation by dendritic cells, initiating cytosolic processing of antigen after inducing dendritic cell maturation. The implications of these studies for understanding CD8(+) T cell activation and implementing novel vaccine strategies is considered.

[Indexed for MEDLINE]

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