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Nat Immunol. 2005 Jan;6(1):65-72. Epub 2004 Dec 19.

Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes.

Author information

1
Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

Erratum in

  • Nat Immunol. 2005 Feb;6(2):219.

Abstract

Signaling through the T cell antigen receptor leading to elimination (negative selection) or differentiation (positive selection) of developing thymocytes generates a self-tolerant T cell repertoire. Here we report that the serine-threonine kinase MINK selectively connects the T cell receptor to a signaling pathway that mediates negative but not positive selection. Analysis of this pathway suggested that the essential function of MINK in the elimination of self-reactive thymocytes may be associated with 'downstream' activation of Jun kinase and enhancement of expression of the proapoptotic molecule Bim.

PMID:
15608642
DOI:
10.1038/ni1145
[Indexed for MEDLINE]

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