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Adv Otorhinolaryngol. 2005;62:49-57.

Function and importance of p63 in normal oral mucosa and squamous cell carcinoma of the head and neck.

Author information

1
Department of Medical Biosciences/Pathology, Umeå University, Sweden.

Abstract

BACKGROUND/AIMS:

Squamous cell carcinoma of the head and neck (HNSCC) is the 6th most common malignancy worldwide with a 5-year survival that has not improved over the last 20-25 years. Factors of prognostic significance for this tumour type include the presence of regional lymph node metastasis and amplification of chromosome 3q21-29, where the p63 gene is located. This gene encodes 6 proteins and is crucial for formation of the oral mucosa, teeth, salivary glands and skin. Each of the 6 different p63 proteins has different characteristics and functions, where some resemble the tumour suppressor protein p53, whilst others have functions that oppose p53.

METHODS:

To understand the function and importance of p63 in oral mucosa and tumour development we have studied protein as well as mRNA expression in normal oral mucosa and tumours.

RESULTS/CONCLUSION:

Expression of p63 proteins differs between the cell layers in normal oral mucosa, and primary HNSCC has a high expression level of p63 isoforms normally expressed in basal cells. Data suggest that p63 expression in HNSCC influences tumour cell differentiation.

PMID:
15608417
DOI:
10.1159/000082464
[Indexed for MEDLINE]

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