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Appl Radiat Isot. 2005 Mar;62(3):383-7.

Cyclotron production of Ac-225 for targeted alpha therapy.

Author information

1
European Commission, Joint Research Centre, Institute for Transuranium Elements, P.O. Box 2340, 76125 Karlsruhe, Germany.

Abstract

The feasibility of producing Ac-225 by proton irradiation of Ra-226 in a cyclotron through the reaction Ra-226(p,2n)Ac-225 has been experimentally demonstrated for the first time. Proton energies were varied from 8.8 to 24.8 MeV and cross-sections were determined by radiochemical analysis of reaction yields. Maximum yields were reached at incident proton energies of 16.8 MeV. Radiochemical separation of Ac-225 from the irradiated target yielded a product suitable for targeted alpha therapy of cancer.

PMID:
15607913
DOI:
10.1016/j.apradiso.2004.06.013
[Indexed for MEDLINE]

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