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Mol Immunol. 2005 Feb;42(4):385-95.

Peripheral NK cell phenotypes: multiple changing of faces of an adapting, developing cell.

Author information

1
Department of Microbiology and Immunology, Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107, USA. bice.perussia@mail.tju.edu

Abstract

We have defined the existence of developmental relationships among human peripheral NK cells with distinct phenotypic and functional characteristics. These findings closely parallel the changes that occur in vivo during NK cell development, and in vitro in experimental culture systems supporting NK cell generation from hematopoietic progenitors. These new insights provide a simplified framework to understand NK cell immunobiology and the cellular bases for their roles in innate immunity, initiation and maintenance of immune responses via regulation of adaptive and accessory cell functions, and immune pathologies.

PMID:
15607789
DOI:
10.1016/j.molimm.2004.07.017
[Indexed for MEDLINE]
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