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J Heart Lung Transplant. 2004 Dec;23(12):1451-4.

Successful treatment of Fusarium proliferatum pneumonia with posaconazole in a lung transplant recipient.

Author information

1
Department of Hematology and Oncology, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, 67098 Strasbourg, France. raoul.herbrecht@chru-strasbourg.fr

Abstract

A 62-year-old lung transplant recipient had Fusarium proliferatum pneumonia during itraconazole prophylaxis. Severe dyspnea and emphysema ensued, requiring supplemental oxygen therapy. Therapeutic options for this patient were limited; renal insufficiency and cyclosporine use precluded amphotericin B therapy, and susceptibility testing indicated that itraconazole and fluconazole had poor activity against F proliferatum. Treatment with posaconazole, a new triazole in clinical development for the prophylaxis and treatment of fungal infection, resulted in rapid clinical improvement and successful eradication of F proliferatum. Posaconazole may provide effective treatment for difficult-to-treat Fusarium infections.

PMID:
15607679
DOI:
10.1016/j.healun.2003.09.033
[Indexed for MEDLINE]

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