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J Neurol Sci. 2005 Jan 15;228(1):11-3.

Interleukin-8, intercellular adhesion molecule-1 and tumour necrosis factor-alpha gene polymorphisms and the risk for multiple system atrophy.

Author information

1
Neurology Service, University Hospital Marqués de Valdecilla, University of Cantabria, 39008 Santander, Spain.

Abstract

In a case-control study using a clinically well-defined group of 41 multiple system atrophy (MSA) patients and 93 control subjects, the interleukin (IL)-8 (-251) TT genotype was associated with an approximately fourfold increased risk for MSA and, furthermore, this risk increased elevenfold with the simultaneous presence of the intercellular adhesion molecule-1 (ICAM-1: E469K) KK genotype, suggesting a gene-gene interaction. These data support a role for inflammation-related genes in risk for MSA.

PMID:
15607204
DOI:
10.1016/j.jns.2004.09.023
[Indexed for MEDLINE]

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