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Clin Microbiol Infect. 2004 Dec;10(12):1098-101.

Synergic in-vitro activity of imipenem and sulbactam against Acinetobacter baumannii.

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Department of Internal Medicine and AIDS Research Institute, BK21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.


The interaction between sulbactam and imipenem was evaluated with four clinical isolates of Acinetobacter baumannii, including two isolates resistant to imipenem, one of which produced IMP-1 metallo-beta-lactamase. Two isolates (one of which was imipenem-resistant) were sulbactam-resistant by undefined mechanisms. MICs were determined by standard broth microdilution methods. Time-kill assays with imipenem and sulbactam, alone or in combination at 0.5 x MIC and 1 x MIC, showed a synergic effect in all four isolates of A. baumannii after incubation for 0, 4, 8 and > 24 h at 35 degrees C.

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