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Org Lett. 2004 Dec 23;6(26):4997-9.

Catalytic enantioselective alkynylation of prochiral sp3 C-H bonds adjacent to a nitrogen atom.

Author information

  • 1Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 2K6, Canada.

Abstract

[reaction: see text] The construction of chiral carbon centers via the first catalytic asymmetric alkynylation of prochiral CH2 groups was developed by using a copper-catalyzed double activation of sp3 and sp C-H bonds. Optically active 1-alkynylated tetrahydroisoquinolines were obtained by this method.

PMID:
15606119
DOI:
10.1021/ol047814v
[PubMed - indexed for MEDLINE]
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