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Bioinformatics. 2005 Apr 15;21(8):1308-10. Epub 2004 Dec 16.

Structural drift: a possible path to protein fold change.

Author information

1
Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323, Harry Hines Blvd, Dallas, TX 75390-9050, USA.

Abstract

SUMMARY:

Along with their mutating sequences, protein structures change in time. Analyzing a formate dehydrogenase domain that is evolutionarily related to ferredoxin, but simultaneously contains all the structural elements of a beta-Grasp fold, we illustrate here a mechanism termed as structural drift, by which changes to a protein fold can occur.

CONTACT:

grishin@chop.swmed.edu.

PMID:
15604105
DOI:
10.1093/bioinformatics/bti227
[Indexed for MEDLINE]

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