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Bioorg Med Chem Lett. 2005 Jan 17;15(2):401-4.

IKCa-channel blockers. Part 2: discovery of cyclohexadienes.

Author information

1
Institute of Medicinal Chemistry, Pharma Research Center, Bayer Health Care, D-42096 Wuppertal, FRG. klaus.urbahns@astrazeneca.com

Abstract

Novel cyclohexadienes have been identified as potent and specific IK(Ca)-channel blockers. In this communication we describe their synthesis as well as their chemical and biological properties. A selected derivative is being enriched in rat brain and reduces the infarct volume, intracranial pressure as well as the water content in a rat subdural hematoma model of traumatic brain injury after iv administration.

PMID:
15603962
DOI:
10.1016/j.bmcl.2004.10.063
[Indexed for MEDLINE]

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