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Bioorg Med Chem Lett. 2005 Jan 17;15(2):373-8.

A novel series of potent gamma-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core.

Author information

1
Department of Medicinal Chemistry, Merck Sharp & Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, UK. stephen_lewis@merck.com

Abstract

A new series of gamma-secretase inhibitors was developed from an in-house screening hit based on a benzobicyclo[4.2.1]nonane core. Lead optimisation studies led to the development of a series of potent inhibitors and in vivo efficacy was demonstrated.

PMID:
15603957
DOI:
10.1016/j.bmcl.2004.10.062
[Indexed for MEDLINE]

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