Format

Send to

Choose Destination
Neuron. 2004 Dec 16;44(6):1011-20.

Competing for memory: hippocampal LTP under regimes of reduced protein synthesis.

Author information

1
Max-Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 München-Martinsried, Germany.

Abstract

The persistence of synaptic potentiation in the hippocampus is known to depend on transcription and protein synthesis. We report here that, under regimes of reduced protein synthesis, competition between synapses for the relevant intracellular proteins can be demonstrated. Under such circumstances, the induction of additional protein synthesis-dependent long-term potentiation for a given set of postsynaptic neurons occurs at the expense of the maintenance of prior potentiation on an independent pathway. This new phenomenon, which we call "competitive maintenance," has important functional consequences, and it may be explained in terms of dynamic interactions between synapses and "plasticity factors" over extended periods of time.

Comment in

PMID:
15603743
DOI:
10.1016/j.neuron.2004.10.033
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center