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Cancer Immunol Immunother. 2005 May;54(5):409-13. Epub 2004 Dec 16.

Harnessing host immune responses to preneoplasia: promise and challenges.

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Laboratory of Tumor Immunology and Immunotherapy, Rockefeller University, New York, NY 10021, USA.


Preneoplastic lesions are more common than clinical cancer and define a population at increased risk for the development of malignancy. Recent studies suggest that the immune system has the capacity to recognize these lesions, and enrichment of preneoplasia-specific immune effectors can be detected in the tumor bed of some preneoplastic lesions such as monoclonal gammopathies. Here, I discuss the promise and challenges of harnessing the immune response against preneoplasia. Approaches to boost the natural host response to these lesions may have a major impact on reducing net cancer burden.

[Indexed for MEDLINE]

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