Format

Send to

Choose Destination
Nature. 2004 Dec 16;432(7019):822.

Neurosurgery: functional regeneration after laser axotomy.

Author information

1
Department of Applied Physics, Ginzton Laboratory, Stanford University, Stanford, California 94305, USA.

Abstract

Understanding how nerves regenerate is an important step towards developing treatments for human neurological disease, but investigation has so far been limited to complex organisms (mouse and zebrafish) in the absence of precision techniques for severing axons (axotomy). Here we use femtosecond laser surgery for axotomy in the roundworm Caenorhabditis elegans and show that these axons functionally regenerate after the operation. Application of this precise surgical technique should enable nerve regeneration to be studied in vivo in its most evolutionarily simple form.

PMID:
15602545
DOI:
10.1038/432822a
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center