Format

Send to

Choose Destination
Hum Genomics. 2003 Nov;1(1):30-40.

Reconstructing the genomic architecture of mammalian ancestors using multispecies comparative maps.

Author information

1
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA. murphywi@mail.ncifcrf.gov

Abstract

Rapidly developing comparative gene maps in selected mammal species are providing an opportunity to reconstruct the genomic architecture of mammalian ancestors and study rearrangements that transformed this ancestral genome into existing mammalian genomes. Here, the recently developed Multiple Genome Rearrangement (MGR) algorithm is applied to human, mouse, cat and cattle comparative maps (with 311-470 shared markers) to impute the ancestral mammalian genome. Reconstructed ancestors consist of 70-100 conserved segments shared across the genomes that have been exchanged by rearrangement events along the ordinal lineages leading to modern species genomes. Genomic distances between species, dominated by inversions (reversals) and translocations, are presented in a first multispecies attempt using ordered mapping data to reconstruct the evolutionary exchanges that preceded modern placental mammal genomes.

PMID:
15601531
PMCID:
PMC3525001
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center