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J Am Chem Soc. 2004 Dec 22;126(50):16288-9.

Use of a retroinverso p53 peptide as an inhibitor of MDM2.

Author information

1
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

Abstract

An N-terminal helical region of the tumor suppressor p53 binds in a hydrophobic cleft of the oncoprotein MDM2. A retroinverso isomer of the natural N-terminal helical peptide was found to interact with MDM2 using the same hydrophobic residues, Phe, Trp, and Leu. We propose that the retroinverso d-peptide adopts a right-handed helical conformation to achieve functional mimicry of the p53 peptide.

PMID:
15600307
DOI:
10.1021/ja044883w
[Indexed for MEDLINE]

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