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Blood. 2005 Apr 1;105(7):2887-90. Epub 2004 Dec 14.

Abnormal interleukin-7 function in common variable immunodeficiency.

Author information

1
Section of Clinical Immunology and Infectious Diseases, Medical Center, Oslo, Norway. a.m.holm@klinmed.uio.no

Abstract

Common variable immunodeficiency (CVID) is characterized by low levels of circulating immunoglobulins, leading to frequent infections, particularly of the respiratory tract. Frequently, T-cell abnormalities are observed. Interleukin-7 (IL-7) is involved in the homeostasis of lymphocytes, and may be elevated in lymphopenia. Mutations of genes related to IL-7 may lead to severe immunodeficiency disorders. We report elevated plasma levels of circulating IL-7 in a subgroup of CVID. These patients have increased numbers of circulating CD8+ T cells with decreased apoptosis and a predominance of CC chemokine receptor 7- (CCR7-) effector-memory T cells. Moreover, in some of these patients there is impaired response to IL-7 as assessed by in vitro proliferation and secretion of interferon gamma and transforming growth factor beta. These findings suggest novel pathogenic mechanisms and specific targets for further research in CVID.

PMID:
15598813
DOI:
10.1182/blood-2004-06-2423
[Indexed for MEDLINE]
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