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Oral Oncol. 2005 Jan;41(1):31-7.

The results of CO2 laser surgery in patients with oral leukoplakia: a 25 year follow up.

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Department of Oral and Maxillofacial Surgery, Groningen University Hospital, P.O. Box 30001, 9700 RB Groningen, The Netherlands.


Oral leukoplakia is an important premalignant lesion of the oral mucosa. We treat this lesion prophylactically with CO2 laser evaporation. In the period from 1976 to 2001, a group of 200 patients with 282 oral leukoplakias were treated by CO2 laser evaporation. In a follow up period of 1-219 months (mean 52), 251 treated leukoplakias (89.0%) did not show a recurrence. Twenty eight (9.9%) local recurrences were observed in 5 to 168 months after treatment. Three (1.1%) squamous cell carcinoma, occurred in the treated area respectively 7, 17 and 19 month after CO2 laser evaporation. This large study with a long follow up shows that laser treatment is a good prophylactic treatment for oral leukoplakia.

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