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Eur J Gynaecol Oncol. 2004;25(6):707-12.

Ultrasonographic criteria and tumor marker assay are good procedures for the diagnosis of ovarian neoplasia in preselected outpatients.

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1
Discipline of Gynecology and Obstetrics, Faculty of Medicine of Triângulo Mineiro, Uberaba-MG, Brazil.

Abstract

PURPOSE OF INVESTIGATION:

To identify parameters for the diagnosis of ovarian neoplasia using ultrasonography (US) and serum tumor marker (TM: CA125, CA19.9, CA15.3, AFP, CEA and estradiol) assay.

METHODS:

Prospective study which included 373 women with increased ovarian volume (> 18 cm3 in premenopause and > 8 cm3 in postmenopause). US criteria (> or = 1) for surgery were: persistent (> 4 months) or increased cyst, cysts with > 1 thick septum or > or = 2 thin septa, cyst diameter > or = 7 cm, vegetation, calcification or cystic predominance (> 50%), solid tumor (> 50%). Doppler with a resistance index (RI) < 0.4 was considered abnormal.

RESULTS:

Laparotomy was performed in 164 (44%) patients with 66 (40.2%) benign neoplasias and 19 (11.6%) malignant cases (73.6% at Stage I or II). Two hundred and nine patients were maintained on clinical follow-up. The sensitivity for neoplasia and malignant neoplasia was, respectively, for RI: 17 and 63.6 and RI plus TM: 53.1 and 90.9.

CONCLUSION:

Ultrasound criteria and TM assay were indicated for the diagnosis of ovarian neoplasia.

PMID:
15597847
[Indexed for MEDLINE]
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