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BMJ. 2005 Jan 8;330(7482):63. Epub 2004 Dec 13.

Risk of ischaemic stroke in people with migraine: systematic review and meta-analysis of observational studies.

Author information

1
Division of Epidemiology, Royal Victoria and Vancouver Hospitals, Canada. Mahyar.etminan@mail.mcgill.ca

Erratum in

  • BMJ. 2005 Mar 12;330(7491):596.
  • BMJ. 2005 Feb 12;330(7487):345.

Abstract

OBJECTIVE:

To explore the association between migraine and risk of ischaemic stroke.

DESIGN:

Systematic review and meta-analysis.

DATA SOURCES:

Observational studies published between 1966 and June 2004 (identified through Medline and Embase) that examined the association between migraine and risk of ischaemic stroke.

RESULTS:

14 studies (11 case-control studies and 3 cohort studies) were identified. These studies suggest that the risk of stroke is increased in people with migraine (relative risk 2.16, 95% confidence interval 1.89 to 2.48). This increase in risk was consistent in people who had migraine with aura (relative risk 2.27, 1.61 to 3.19) and migraine without aura (relative risk 1.83, 1.06 to 3.15), as well as in those taking oral contraceptives (relative risk 8.72, 5.05 to 15.05).

CONCLUSIONS:

Data from observational studies suggest that migraine may be a risk factor in developing stroke. More studies are needed to explore the mechanism of this potential association. In addition, the risk of migraine among users of oral contraceptives must be further investigated.

Comment in

PMID:
15596418
PMCID:
PMC543862
DOI:
10.1136/bmj.38302.504063.8F
[Indexed for MEDLINE]
Free PMC Article
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