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Acta Neurol Scand. 2005 Jan;111(1):12-20.

Does L-dopa treatment contribute to reduction in body weight in elderly patients with Parkinson's disease?

Author information

1
Division of Neurology, Department of Neuroscience and Locomotion, Linköping University, Linköping, Sweden. sven.palhagen@neuromedicin.se

Abstract

OBJECTIVE:

Many patients with Parkinson's disease (PD) lose weight also early during the disease. The objective of the study was to investigate possible causative factors for this loss.

MATERIALS AND METHODS:

In this report, 28 PD patients and 28 age- and sex-matched controls were repeatedly assessed with the focus on body weight, body fat mass, dysphagia, olfaction, physical activity, PD symptomatology and drug treatment.

RESULTS:

Weight loss was seen in PD patients both before and during L-dopa treatment.

CONCLUSION:

The underlying disease could play a role, but our results also suggest that L-dopa per se could contribute to the weight loss.

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