Format

Send to

Choose Destination
Int J Med Microbiol. 2004 Oct;294(6):395-9.

Flagella-mediated bacterial motility accelerates but is not required for Salmonella serotype Enteritidis invasion of differentiated Caco-2 cells.

Author information

1
Department of Pathobiology, Division Pathology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, PO Box 80.158, 3508 TD Utrecht, The Netherlands. f.asten@vet.uu.nl

Abstract

The relative contributions of the flagellum and the flagella-associated bacterial motility in the invasion of Caco-2 cells by Salmonella serotype Enteritidis were investigated using an fliC mutant defective in flagellin production and a motA mutant that carries flagella but is non-motile. Infection assays demonstrated that, at 1 h of infection, both the fliC and the motA mutants were severely impaired in bacterial invasion compared to the parental strain. Infection assays at 3 h infection demonstrated virtually equal invasion levels for both non-motile mutants and the parental strain. Together these data suggest that flagella-mediated bacterial motility accelerates the invasion of Salmonella but is not required for the invasion event per se.

PMID:
15595389
DOI:
10.1016/j.ijmm.2004.07.012
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center