Format

Send to

Choose Destination
See comment in PubMed Commons below
Bioinformatics. 2003 Sep 1;19(13):1710-1.

Detecting putative orthologs.

Author information

1
Department of Biological Sciences, Stanford University, CA 94305, USA. dpwall@stanford.edu

Abstract

We developed an algorithm that improves upon the common procedure of taking reciprocal best blast hits(rbh) in the identification of orthologs. The method-reciprocal smallest distance algorithm (rsd)-relies on global sequence alignment and maximum likelihood estimation of evolutionary distances to detect orthologs between two genomes. rsd finds many putative orthologs missed by rbh because it is less likely than rbh to be misled by the presence of a close paralog.

PMID:
15593400
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center