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Nat Neurosci. 2005 Jan;8(1):18-9. Epub 2004 Dec 12.

Insulin signaling in the nervous system regulates ethanol intoxication in Drosophila melanogaster.

Author information

1
Department of Anatomy and Programs, University of California, San Francisco, California 94143-2822, USA.

Abstract

The insulin signaling pathway regulates multiple physiological processes, including energy metabolism, organismal growth, aging and reproduction. Here we show that genetic manipulations in Drosophila melanogaster that impair the function of insulin-producing cells or of the insulin-receptor signaling pathway in the nervous system lead to increased sensitivity to the intoxicating effects of ethanol. These findings suggest a previously unknown role for this highly conserved pathway in regulating the behavioral responses to an addictive drug.

PMID:
15592467
DOI:
10.1038/nn1363
[Indexed for MEDLINE]

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